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Tannic acid exerts anti-apoptotic activity by down-regulating the caspase-3, Bax, and up-regulating Bcl-2, and activates the antioxidant defense system by up-regulating Nrf2 and HO-1 (Zhang et al., 2017)
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However, recent research and expert opinions have clarified that niacinamide and vitamin C can be safely combined in the same routine
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