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Embodiment 3 [0107] On the basis of Example 1, the condensing agent used when coupling Boc-His(Trt)-Aib-OH was replaced by HATU / DIEA, and the obtained semaglutide crude peptide HPLC detection results were as follows Image 6 As shown, the purity of semaglutide is 71.369%, and the maximum unmixed value is 4.609%