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This data can be accessible at: Abbreviations ADA: American Diabetes Association ALP: Alkaline phosphatase BMC: Bone mineral content BMD: Bone mineral density CDC: Centers for Disease Control and Prevention DAVID: Database for Annotation, Visualization and Integrated Discovery DXA: Dual-energy X-ray absorptiometry FAD: Flavin adenine dinucleotide FMN: Flavin mononucleotide GO: Gene Ontology GSH: Reduced glutathione GSSG: Oxidized glutathione KEGG: Kyoto Encyclopedia of Genes and Genomes MEC: Mobile Examination Center MET: Metabolic equivalent task NHANES: National Health and Nutrition Examination Survey PA: Physical activity PPIs: Protein-protein interactions RCS: Restricted cubic spline References Ensrud KE, Crandall CJ, Osteoporosis
Mol Neurobiol 56:513524
Notably, the age-related increases in nitration of ECM-bound HGF were predominant on fast IIa and IIx myofibers 32 , corresponding with the fast fiber-preference observed in age-related muscle atrophy and impaired regeneration in humans in which fast IIb fibers are scarce 33,34,35, 39
mTORC1 phosphorylates and activates p70S6K which in turn phosphorylates ribosomal protein S6 to enhance translation efficiency 23
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