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In the parent study, 24 weeks of low-dose semaglutide (1 mg subcutaneously weekly) significantly reduced IHTG by 31.3%, improved insulin sensitivity (approximately 1.5-unit decrease in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)), and lowered triglyceride levels by 27 mg/dL 12

Mitochondrial energy metabolism and thyroid cancers

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Staying hydrated and avoiding excessive doses helps prevent these issues

The ongoing trends include a growing use of oral formulations of GLP-1 together with long-acting injectables, integration of digital health tools for adherence, and a focused approach to real-world evidence studies that provide long-term outcomes