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173 At the molecular level, gene modulation techniques, including siRNA- and shRNA-mediated silencing of efflux transporter genes (e.g., ABCB1, ABCG2), as well as CRISPR/Cas9-based gene editing, have successfully resensitized tumor cells to chemotherapy in preclinical models
Conversely, participants receiving GLP-1 RAs were consistently more likely to report experiencing gastrointestinal side effects
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Restoration of IGF-1 through administration or increased endogenous production has demonstrated improvements in lipid profiles, reduced adipose tissue accumulation, and enhanced metabolic health markers
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