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Although HSF2 is not the primary initiator of heat stress, it acts in concert with HSF1 during spermatogenesis to ensure the integrity of basal HSP expression and stress-induced responses (Himanen et al., 2022)

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In the Methods, we explain why we take the multiplier, S , of the V max values of GCL and GPX to have the following dependence on estradiol, E 2: Thus, since male E 2 is 0.09 nM [26] , S = 1 for the male