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Lyu F, Hu Y, Wang L, Sun W (2021) Dealkalization processes of bauxite residue: A comprehensive review
While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician
Key areas analyzed included the prelimbic cortex, anterior olfactory nucleus, nucleus accumbens, lateral septal nucleus, bed nucleus of stria terminalis, ventral reuniens, paraventricular and ventromedial hypothalamic nuclei, hippocampal CA1 and CA2/3 regions, and the central amygdaloid nucleus
Since B12 is a water-soluble vitamin, excess amounts are typically eliminated through urine