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This can lead to fatigue, lethargy, and even resistance to weight loss, resulting from a slowed metabolism

Thyroid concerns arose during drug development due to C-cell hyperplasia and medullary thyroid carcinoma seen in rodent studies

Mostly older animal work, one small human pharmacokinetic study, and one human trial that did not beat placebo

The Phase 2 trial results speak for themselves: up to 24% body weight reduction at the highest dose (12mg/week) in 48 weeks, with 25% of patients losing 30% or more of their starting weight

Indeed, the high risk of fish contamination by environmental pollutants cannot be ignored