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Interestingly, only a very small amount of GLP-1R is present in the -cell membrane, but GLP-1 can inhibit glucagon secretion in human pancreatic islets by directly acting on GLP-1R on -cells
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The activation of the GIP receptor in the arcuate, dorsomedial and paraventricular nuclei of the hypothalamus decreased food intake in obese mice
Its multi-receptor activity gives it a broader research profile than more selective melanocortin agonists
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