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10.1016/j.clinbiochem.2009.03.011
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Severe cases may progress to alopecia totalis (AT) or alopecia universalis (AU).5 AA can have a substantial impact on quality of life, including psychosocial burden related to comorbid conditions such as anxiety and depression.2 Additionally, AA is associated with several comorbidities, including thyroid disease, psoriasis, vitamin D deficiency, and other autoimmune disorders.6 The pathogenesis of AA involves loss of immune privilege in the hair follicle (HF) and the subsequent recognition of exposed autoantigens by autoreactive CD8+ T cells through their T-cell receptor (TCR)
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