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Obesity disrupts bone metabolism and leads to increased bone resorption, but GLP-1RAs can inhibit this damage and improve bone health by increasing the OPG/RANKL ratio, reducing osteoclast activity, and promoting bone formation
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Semaglutide has a half-life of approximately 7 days because it is structurally modified to resist DPP-4 degradation and bind to albumin in the blood, creating a slow-release reservoir
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