[3][4] For practitioners evaluating Retatrutide alternatives for weight loss, the primary approved options are Tirzepatide, an FDA-approved dual GLP-1/GIP receptor agonist (Mounjaro/Zepbound), and Semaglutide, an FDA-approved GLP-1 receptor agonist (Ozempic/Wegovy)
Key Takeaways Tirzepatide vs semaglutide comes down to dual agonist vs single agonist: tirzepatide targets both GLP-1 and GIP receptors, while semaglutide targets GLP-1 alone The only head-to-head trial (SURPASS-2) found tirzepatide superior to semaglutide for both blood sugar control and weight loss In separate obesity trials, tirzepatide 15mg achieved 20.9% weight loss at 72 weeks vs semaglutide 2.4mg's 14.9% at 68 weeks Semaglutide has proven cardiovascular benefit (SELECT trial: 20% MACE reduction)
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Cell 179 , 14831498.e22 (2019)
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