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In some HIV-seropositive subjects, this may trigger oral mucosal melanin hyperpigmentation [6, 14]
The peptide works by binding to the melanocortin receptors 1, 3, 4, and 5 (MC1R, MC3R, MC4R, MC5R), with high affinity at MC1R, with the effect of increasing melanin production and tanning in research subjects [1, 2, 3]
Accordingly, this review focuses on mechanistic integration rather than exhaustive coverage of each individual domain (Panagiotou et al., 2021
SOX10 is present in 70% of cases
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