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They have been known to trigger attacks in sensitive individuals (WebMD)
Dosing at a Glance: Indication Dose: - Acetaminophen poisoning (IV) Load 150 mg/kg over 1h, then 15 mg/kg/h for 12h - Acetaminophen poisoning (oral) Load 140 mg/kg, then 70 mg/kg q4h x 17 doses
Phase 3 studies are typically designed as randomized, double-blind, placebo-controlled trials, which means that neither the participants nor the researchers know which treatment each participant is receiving
Operation of the pathway in vivo: unresolved issues The ascorbateglutathione pathway as understood today does not easily lend itself to the use of nuclear isotopes to estimate metabolic flux between the different reactions
