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The GSH synthesis enhancer N-acetylcysteine (NAC) can restore the GSH level of PMN-MDSCs, but high doses may induce oxidative stress (182)

Cardiovasc Res 75:2208, PMID: 17451659 Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I (2004) S -glutathionylation: from redox regulation of protein functions to human diseases

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While no formal clinical trials of this specific combination have been publicly reported as of early 2026, the theoretical basis for synergy is compelling based on the distinct yet complementary mechanisms of each compound [5]