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However, in a chronic model based on cuprizone treatment associated with rapamycin to inhibit OPC differentiation so as to improve reproduction of the characteristics of chronic MS, remyelination was faster and more robust in the cortex than in the CC (Bai et al., 2016), as observed in patients with chronic MS (Chang et al., 2012)

Initial Phase: 2 to 4 Weeks In the early weeks, subtle improvements begin to appear