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2291-C DASATINIB AND QUERCETIN AS SENOLYTICS ATTENUATE FAT DEPOSITION AND HAVE ANTIFIBROTIC EFFECTS IN MEDAKA NONALCOHOLIC STEATOHEPATITIS MODEL Hiroyuki Abe 1 , Shunta Yakubo 1 , Norihiro Sakai 1 , Yusuke Watanabe 1 , Naruhiro Kimura 1 , Toru Setsu 1 , Takeshi Yokoo 1 , Akira Sakamaki 1 , Hiroteru Kamimura 1 , Atsunori Tsuchiya 1 , Kenya Kamimura 2 and Shuji Terai 1 , (1)Graduate School of Medical and Dental Sciences, Niigata University, (2)School of Medicine, Niigata University Background: Non-alcoholic steatohepatitis (NASH) is known to cause cellular senescence due to the effects of oxidative stress, endoplasmic reticulum stress, and autophagy in the liver caused by ectopic fat deposition
Light to moderate alcohol use may be safe, but it can worsen symptoms like nausea or dizziness
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