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The New England Journal of Medicine, 373 (1), 1122
PubMed Central, Dong, Shichao, and Chuan Sun
Phase IIb Dose-Finding Clayton et al
When HNMT enzyme activity is reduced due to genetic variants, histamine can accumulate in the central nervous system, contributing to anxiety, irritability, brain fog, and sleep disruption
But, they can also slow down stomach movement, which might lead to gastroparesis
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