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GLP-1 is a naturally occurring hormone critical for appetite regulation and glucose metabolism
GLP-1 inhibits agouti-related peptide and hypothalamic neuropeptide Y for homeostatic appetite regulation, reducing hunger, and increasing satiety
Participants also saw significant improvements in blood pressure, cholesterol, and insulin resistance
Additionally, for the outcome of completed suicide, the generalizability of findings to the broader population of interest was limited (indirectness), as the evidence largely originated from studies involving overweight or obese patients with severe metabolic comorbidities
In a 2026 clinical trial published in Nature Medicine , participants who switched from injectable GLP-1 drugs to the once-daily pill orforglipron maintained roughly 75% to 79% of their prior weight loss
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