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In a 2017 study using human vascular endothelial cells and a chick chorioallantoic membrane assay, Hsieh and colleagues reported that BPC-157 exposure increased VEGFR2 mRNA and protein expression, promoted VEGFR2 internalization (an effect blocked by the endocytosis inhibitor dynasore), and time-dependently activated the VEGFR2-Akt-eNOS axis without a corresponding increase in VEGF-A (Hsieh et al., 2017)
These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations
Changes in Glutathione Content in Liver Diseases: An Update
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Effects of DSIP on Biomarkers of Aging, Life Span, and Tumor Incidence in Female Mice
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