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Compounds (3,5-Odicaffeoyl-d-quinic acid and matesaponin-2 and linolenic acid exhibited significant elevations in GLP-1 levels [33]
doi: 10.3389/fpsyt.2026.1893173 Received 28 May 2026 Revised 16 June 2026 Accepted 16 June 2026 Published 24 July 2026 Volume 17 - 2026 Edited by Matej Stuhec, University of Maribor, Slovenia Reviewed by Borjanka Batinic, University of Belgrade, Serbia Miodrag Janic, University Medical Centre Ljubljana, Slovenia Updates Copyright 2026 Alanazi and Alanazi
Upregulation of GGT activity is primarily dependent on the Ras protein and its downstream effectors, which include extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/AKT and c-Jun N-terminal kinase (JNK) signaling pathways (Fig
91 In addition, lactylation at K91 of TFEB inhibits its interaction with the E3 ubiquitin ligase WWP2, leading to reduced ubiquitination and proteasomal degradation of TFEB, thereby resulting in enhanced TFEB activity
It's a thermogenic effect from glucagon activation not a fever, not organ stress
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