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I've done a clinical trial in humans
In one human study, scientists found that applying a cream containing alpha-lipoic acid to the skin reduced fine lines, wrinkles, and skin roughness with no side effects ( When alpha-lipoic acid is applied to the skin, it incorporates itself into the skins inner layers and offers antioxidant protection against the suns harmful UV radiation (19, Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as glutathione, which help protect against skin damage and may reduce signs of aging (21, May slow memory loss Memory loss is a common concern among older adults
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The FDA labeling also includes important warnings about risks of pancreatitis, acute gallbladder disease, and a boxed warning regarding thyroid C-cell tumors
it's a documented concern in healthcare and pharmaceuticals circles
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