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Data from the STEP [52] and SUSTAIN [53, 54] trials consistently demonstrate that the substantial weight loss achieved with semaglutide at doses of 0.5 mg, 1.0 mg, and 2.4 mg is largely independent of these symptoms, with less than 1% of the total weight loss benefit attributable to GI AEs
Ametrine-1 (NCT06589986) is a treat-through study examining both induction and maintenance therapy over 52 weeks in 400 participants
The SURPASS trials demonstrated that tirzepatide 15mg achieved up to 22.5% body weight reduction in participants with obesity, compared to approximately 15-17% with semaglutide 2.4mg in the STEP trials
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