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By strategically combining the power of a GLP-1 agonist with the energy-producing properties of B12, this compounded drug aims to enhance your results and improve how you feel
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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity
Featuring 94% sequence homology to endogenous human GLP-1, this 31-amino acid polypeptide incorporates two critical structural modifications: an aminoisobutyric acid (Aib) substitution at position 8 to prevent degradation by the DPP-4 enzyme, and the attachment of a C18 fatty diacid via a hydrophilic spacer
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