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[3] Any menstrual changes are therefore most likely mediated through: Metabolic improvements (reduced insulin resistance, weight loss) Changes in adipose tissue and associated hormone production Restoration of hypothalamic-pituitary-ovarian axis function in women with metabolic dysfunction According to NICE guidance (NG28), GLP-1 receptor agonists like semaglutide are recommended for type 2 diabetes when specific criteria are met, typically in combination with other diabetes medications when treatment targets are not achieved

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