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Yes, stacking is possible
doi: 10.3389/fimmu.2020.00827 64 Diaz-VivancosP.WolffT.MarkovicJ.PallardF
Phase 2 offers a variety of processes (methylation, amino acid conjugation and sulfation) to bind to these toxic intermediates and neutralize them
To minimize adverse effects, taking a secondary medication with a complementary mode of action is advisable before taking the initial drug at the maximum recommended dose (143)
doi: 10.1177/1179573517693596
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