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A biosimilar applicant can opt out, accepting that the reference product sponsor retains more control over which patents to litigate first and on what timeline
Luan et al
Insufficient protein intake accelerates muscle loss during weight loss
In the trial, 18.2% of patients discontinued the high dose and 12.2% the lower dose due to adverse events, compared to the much lower 4% discontinuation rate in the placebo arm
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