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Fundamentally, aging is driven by the cumulative effects of cellular senescence (Arianna et al., 2019)
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Cultures were maintained in a humidified atmosphere of 5% CO 2 at 37C for 24 h and then incubated for the next 24-h period in DMEM-10% HS additionally containing recombinant HGF that was treated with peroxynitrite with or without trisulfide pre-treatment (see Figure 1d,f)
The study also suggests that this peptide increases the rate of fibroblast movements into damaged tissue, which helps facilitate faster wound healing
