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2.2.3 Beyond the eye In renal tubular cells (Wang et al., 2021) and brain tissue in animal stroke model (He et al., 2020), exenatide and liraglutide activate NAD + -dependent deacetylase SIRT1, reducing mitochondrial dysfunction and oxidative stress by decreasing ROS production, thereby preventing apoptosis induced by lipotoxicity
High glucose availability limits the ability of fatty acids to get inside the mitochondria, so fatty acid oxidation goes down and the mitochondria predominantly oxidize glucose for energy
Evidence is promising but still emerging, especially for long-term hair-specific outcomes
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