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Hence, GLP-1R is able to couple not only to G s , but also to other G subtypes including G i and G q
The efficacy and safety of once-weekly semaglutide have been established in the SUSTAIN (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) clinical trial programme across the continuum of care in individuals with type 2 diabetes vs placebo and a range of comparators (SUSTAIN 15 and 710) [11,12,13,14,15,16,17,18,19] and in a cardiovascular outcomes trial (SUSTAIN 6) [20]
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Better glycemic control reduces oxidative stress and vascular inflammation, potentially improving blood flow to sexual organs and enhancing physiological arousal capacity
Status FDA-approved
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