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A 2022 systematic review in Frontiers in Pharmacology identified 98 preclinical studies but zero controlled human pharmacokinetic trials [1]
Real-world data, published by Epic Research, paints a somewhat different picture
Employers are spending six and seven figures on GLP-1s with no view into adherence, outcomes, or what they're actually getting back
However, variability has been noted between studies, and long-term secretion patterns remain under continued investigation
Note when sleep changed, what else changed, and whether symptoms happen nightly or in waves
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