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This finding underscores the need for new molecules or modifications to MF to overcome MT-Ros3 dependence and enhance treatment efficacy ( Leishmania exhibits remarkable stability, as indicated by a consistent EC50 value, even after prolonged culture without drug exposure
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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response
While glutathione skin whitening and other procedures have benefits, they also have drawbacks
Verrillo, E
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