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This limit was not derived from a toxicity signal at higher frequencies but rather from the design of the RECONNECT trials, where the mean number of doses used per month was approximately 2.5, 3
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Source: Employer Benefit Research Institute April 16, 2026 GLP-1 medications for obesity carry a well-documented discontinuation problem, and stopping them typically means regaining weight and the return of cardiometabolic risk factors
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