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Hydroxyethyl starch inhibits glycocalyx-degrading enzymes, facilitating the restoration of glycocalyx thickness and enhancing expression of VE-cadherin, occludin, and zonula occludens-1, reducing albuminfluorescein isothiocyanate infiltration, and improving pulmonary vascular permeability [45]
Twarog, C
Lancet 383 , 10681083 (2014)
As the newest addition to incretin-based drugs, tirzepatide harbors the potential to counteract most of the pathogenetic mechanisms underpinning CKD in T2D displaying unprecedented features in terms of glucose and weight lowering, accompanied by promotion of insulin sensitivity, control of SBP, dyslipidemia, and biomarkers of inflammation and endothelial dysfunction
Panov J, Simchi L, Feuermann Y, Kaphzan H
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