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Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle

GLP-1 is a peptide hormone that easily crosses the blood-brain barrier, making GLP-1RAs good candidates for treating several neurodegenerative diseases like PD and Alzheimers disease, brain injury, and stroke [40]

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Every week, like clockwork, you step on the scales and the needle is still in the same place

The mechanism is twofold: GHRH activates its cAMP pathway while GHRP partially blocks somatostatin and activates the calcium pathway