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Included in the propensity matching were medications and conditions that could introduce confounding bias such as obstructive sleep apnea, mood disorders, anxiety disorders, chronic pain syndromes, benzodiazepines, and antihistamines
It suppresses the production of gut-protective mediators like resolvin D5n-3 DPA (RvD5n-3 DPA) and the linoleic acid (LA) metabolic pathway, which normally function as aryl hydrocarbon receptor (AHR) ligands to promote Treg differentiation and suppress Th17 responses, thereby exacerbating inflammation ( P.g -induced dysbiosis alters the metabolism of tryptophan, reducing beneficial AHR ligands and increasing metabolites like 3-indoleacrylic acid and N-formylkynurenine, which have been linked to neutrophil activation and neurotoxicity, respectively (Niu et al., 2024
0.8% placebo), with total WL of 6.5% compared to 0.8% with placebo [97]
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