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In the meantime, mitochondrial dysfunction is induced by hepatic IR and lipid accumulation and the lipid peroxidation mediated by cytochrome p450 2E1 boost the production of reactive oxygen and promote the degradation of mitochondria (125), which could further lead to the lack of cellular energy and metabolic intermediates accumulation, all these may lead to the secretion of pro-inflammatory cytokines, hepatocellular apoptosis and hepatic fibrogenesis, finally resulting in cirrhosis of the liver (125) ( Figure 3 )
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The two can act together to reduce stress and help with sleep quality, although L-theanine taken in high doses (above 600 milligrams) may have opposite effects and so may melatonin
Women benefit most when we treat menopause as the metabolic inflection point it isnot just prescribing GLP-1s in isolation, but considering hormone therapy, addressing sleep disruption (which drives cortisol and undermines any weight loss effort), and building strength to counter the lean mass loss these medications can cause
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