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The PPAR agonist rosiglitazone can reproduce exercise-evoked endothelial stabilization and BBB integrity, decreasing the levels of inflammatory mediators and oxidative endothelial injury [263]
A healthy, diverse microbiome is fundamental to mucosal integrity it produces the short-chain fatty acids that fuel the gut lining, crowds out pathogenic overgrowths, and maintains the tight junction proteins that regulate intestinal permeability
A toll-like receptor recognizes bacterial DNA
A probiotic cocktail containing Streptococcus thermophilus , Lactobacillus acidophilus , and Bifidobacterium longum showed no benefit in hemodialysis patients (85), and physical exercise did not modulate gut microbiota-derived uremic toxins in hemodialysis (86)
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