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Although LRRK2 knockout mice can control Mycobacterium tuberculosis replication, they have exacerbated inflammation and lower interferon stimulated gene expression in the lungs
Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines
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Mechanistically, ALA may support lipid metabolism through several pathways:60 Reduces oxidative stress in liver cells ALA works as an antioxidant by neutralizing reactive oxygen species (ROS) unstable molecules that can damage liver cells and interfere with fat metabolism
