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Single-dose vials of Zepbound can now be purchased at Walmart through LillyDirect for $349 per month

This interaction occurs because Ozempic markedly slows gastric emptying, which can substantially impair the absorption of these drugs into the bloodstream

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The jump to 12mg adds a few more percentage points but also significantly increases side effects and discontinuation rates

A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit