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According to the American Diabetes Association, prediabetes can be defined by a condition of impaired fasting glucose, characterized by a fasting blood glucose concentration between 100 mg/dL and 125 mg/dL and/or a condition of impaired glucose tolerance, characterized by a 2-hour blood glucose concentration 140 mg/dL following an oral glucose tolerance test (56)
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A meta-analysis also reported diagnoses of medullary thyroid carcinoma in patients taking GLP-1RAs, reinforcing the at-risk status as a contraindication to GLP-1RA treatment
For perspective, prior to 2023, the top-selling drugs were largely immunology or oncology biologics (like Humira, Keytruda, Eliquis), but by mid-2024, the list transformed GLP-1 agonists entered the top ranks
Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease
