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Sources conflict on whether fosgonimeton is a prodrug of Dihexa or a structurally distinct molecule, so it should not be read as evidence for or against Dihexa specifically only as the nearest human data point in the program, and a negative one

(2021) This placebo-controlled study tested copper tripeptide serum alone, providing a direct comparison point for topical copper peptide efficacy without the 5-ALA component

The FDA also highlights safety concerns regarding certain bulk substances used in compounding, as well as broader compounding risks

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