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Clinical trial data using body-composition analysis show that fat mass accounts for the majority of weight loss, while lean-mass changes reflect normal physiologic adaptation to reduced body weight and energy intake. Understanding this distinction is criticalbecause muscle wasting and expected lean-mass adaptation are not the same thing
However, the protective effects of GLP-1R activation on memory were negated by the administration of exendin (939) and Compound C dihydrochloride (an AMPK inhibitor) [69]
