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The reason is straightforward: tendons and ligaments have poor native blood supply, which means they heal slowly under the best circumstances and often stop progressing entirely after initial recovery
Pera-Kajn and Jakubowski, 2022
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IGF-1 LR3 has a higher binding affinity for IGF-1R and reduced IGFBP binding compared to native IGF-1, meaning free tissue exposure is greater for equivalent doses, which amplifies the theoretical risk
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