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The most frequently reported adverse effects are gastrointestinal in nature , particularly during the initial weeks of treatment and following dose increases

Schernthaner G, Gross JL, Rosenstock J, Guarisco M, Fu M, Yee J, et al

PDI is S-nitrosylated in lumbar spinal cords of sporadic ALS patients (Walker et al., 2010), which abrogates PDI-mediated attenuation of neuronal cell death triggered by ER stress or misfolded proteins (Uehara et al., 2006)