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Brain Ti-EVs are involved in central nervous system disease progression and thus can be used as biomarkers and therapeutic targets (Asai et al
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Allaire J, Vors C, Tremblay AJ, et al
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Despite fewer data are available in PsA patients, short-term studies show a trend toward dose tapering and against treatment discontinuation in patients with well-controlled disease [151], although 55% of PsA patients might remain on remission after anti-TNF- discontinuation [152]
In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role
