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These groups are more at risk because their bodies need more B12
Typical daily intake targets are about 600 IU per day for most adults, and 800 IU per day after age 70
Lastly, Ex-4 also protects the AGE-induced activation of receptor AGE signaling pathway, which is responsible for the inflammation and oxidative stress induced by AGEs [66]
This framing is speculative but scientifically coherent with the known mechanisms
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