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The timing depends on deficiency severity, symptoms, and blood test results

However, GLP-1 medications slow gastric emptying, which may affect absorption of oral HRT formulations, though transdermal or vaginal HRT routes bypass this concern entirely

A previous study has established that the BV-2 cell line derived from microglia can secrete GLP-1 and that GLP-1 secretion is reduced under inflammatory stimulation [107], suggesting a potential autocrine or paracrine role for GLP-1 signaling within microglia

Most patients don't run these tests

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells