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Human chorionic gonadotropin (hCG) is commonly prescribed in the UK alongside testosterone replacement therapy (TRT), particularly where preservation of testicular function or fertility is a clinical consideration

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In addition, deletion of the GSH1 geneencoding glutamylcysteine synthetase (GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)

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