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Individuals with certain MC4R genotypes may experience a weaker subjective appetite reduction from the same GLP-1 dose not because the medication isn't working pharmacologically, but because the downstream receptor response is genetically attenuated

The reduction in heart disease is concomitant to it's LDL-C lowering effect

For example, metalloproteinase inhibitor 4 (TIMP4) was upregulated by semaglutide in STEP 2 but not STEP 1

Both Saxenda and its generic version work the same way in the body